Promethazine HCl and Codeine Phosphate Oral Alternative is indicated for that short-term aid of coughs and upper respiratory signs connected with allergy or the frequent chilly in sufferers 18 several years of age and older.
Codeine has reduced plasma protein binding with about seven to 25% of codeine sure to plasma proteins. Codeine passes the blood Mind barrier plus the placental barrier. Small quantities of codeine and its metabolite, morphine, are transferred to human breast milk.
The codeine and promethazine in Promethazine HCl and Codeine Phosphate Oral Answer may perhaps improve the frequency of seizures in patients with seizure disorders, and will raise the risk of seizures transpiring in other medical configurations involved with seizures.
The specialized storage or access that is made use of completely for statistical needs. The specialized storage or access that may be applied exclusively for nameless statistical needs.
As a consequence of very similar pharmacologic Houses, it's acceptable to count on identical threat with concomitant usage of opioid cough medicines and benzodiazepines, other CNS depressants, or Alcoholic beverages.
Lifestyle-threatening respiratory depression and death have transpired in small children who received codeine; most instances followed tonsillectomy and/or adenoidectomy, and many of the kids had evidence of currently being an extremely-speedy metabolizer of codeine resulting from a CYP2D6 polymorphism. (five.three) Promethazine HCl and Codeine Phosphate Oral Alternative is contraindicated in children young than twelve yrs of age As well as in small children youthful than 18 several years of age adhering to tonsillectomy and/or adenoidectomy.
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There may be other Unwanted side effects of promethazine/codeine that aren't listed in this article. Speak to your Health care supplier if you think that you are getting a facet effect of a drugs.
When employed for an extended time, this medication may well not do the job in addition and should demand distinct dosing. Talk with your physician more info if this medication stops working perfectly.
Stimulation might be evident, especially in young children and geriatric clients. Convulsions may perhaps rarely happen. A paradoxical reaction has been described in small children acquiring one doses of seventy click here five mg to 125 mg orally, characterized by hyperexcitability and nightmares.
Lifestyle-threatening respiration complications (respiratory depression). Promethazine Hydrochloride and Codeine Phosphate Oral Remedy might cause get more info respiratory problems (respiratory despair) that may take place at any time through procedure and can lead to death. Your danger of breathing difficulties is greatest whenever you very first start off using Promethazine Hydrochloride and check here Codeine Phosphate Oral Resolution, are using other medicines that can result in respiration troubles, have specified lung troubles, are aged or have sure other health problems.
Drug dependancy is a cluster of behavioral, cognitive, and physiological phenomena that acquire right after repeated material use and consists of: a powerful need to take the drug, problems in managing its use, persisting in its use Even with dangerous outcomes, a higher precedence supplied to drug use than to other things to do and obligations, increased tolerance, and from time to time a physical withdrawal.
Codeine has long been described to show no proof of carcinogenicity or mutagenicity in a variety of take a look at techniques, such as the micronucleus and sperm abnormality assays as well as the Salmonella assay. Promethazine was nonmutagenic in the Salmonella take a look at method of Ames.